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SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 31 g (About 1 Scoop)
Amount Per Serving
%DV
Calories
120
Total Fat
1.5 g
2%
Saturated Fat
1 g
5%
Cholesterol
60 mg
20%
Sodium
130 mg
6%
Total Carbohydrate
3 g
1%
Total Sugars
2 g
Protein
24 g
48%
Calcium
140 mg
10%
Potassium
150 mg
4%
Top Medical Research Studies
9
Targeted HS delivery alleviates RA
NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of HS into the synovium.
High relevance to RA treatment
We explored a new strategy to treat rheumatoid arthritis (RA) by using nanoparticles to deliver hydrogen sulfide (HS) directly to affected joints. Our research focused on how effectively these nanoparticles, called NaHS@Cy5@MS@SP, could target specific cells involved in inflammation and tissue damage in RA. By slowly releasing HS in the synovium, we aimed to combat the negative effects of inflammation caused by fibroblast-like synoviocytes (FLSs).
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
Read More
9
Hydrogel enhances uveitis treatment
Peptide-based hydrogel co-assembled with antibody-drug for enhanced retinal cell uptake and attenuated experimental autoimmune uveitis.
Directly addresses autoimmune treatment
We investigated a new approach to tackle chronic autoimmune eye diseases like uveitis. Our attention focused on a unique drug delivery system that combines a peptide-based hydrogel with secukinumab (SEK), an antibody specifically designed to neutralize IL-17A. This combination targets retinal pigmented epithelium (RPE) cells, helping to enhance the treatment's effectiveness.
Through our analysis, we found that this SEK-loaded hydrogel significantly improved the uptake of the antibody by RPE cells, achieving an impressive 3.7 times increase compared to using SEK alone. Over a 20-day treatment period, we observed that this method also led to higher drug concentrations in the retinal tissues, indicating a more effective delivery mechanism.
In a model of uveitis, just a single intravitreal injection of the SEK-loaded hydrogel was able to effectively suppress inflammation. Moreover, it positively influenced various factors like reducing the activity of specific immune cells, preserving the integrity of the blood-retina barrier, lessening retinal cell death, and supporting the recovery of retinal function. Overall, our study showcases the promising potential of this innovative delivery system for treating complex autoimmune disorders in the eye.
Through our analysis, we found that this SEK-loaded hydrogel significantly improved the uptake of the antibody by RPE cells, achieving an impressive 3.7 times increase compared to using SEK alone. Over a 20-day treatment period, we observed that this method also led to higher drug concentrations in the retinal tissues, indicating a more effective delivery mechanism.
In a model of uveitis, just a single intravitreal injection of the SEK-loaded hydrogel was able to effectively suppress inflammation. Moreover, it positively influenced various factors like reducing the activity of specific immune cells, preserving the integrity of the blood-retina barrier, lessening retinal cell death, and supporting the recovery of retinal function. Overall, our study showcases the promising potential of this innovative delivery system for treating complex autoimmune disorders in the eye.
Read More
9.5
Calcium's role in RA treatment
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.
Focus on calcium's therapeutic potential
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Read More
Most Useful Reviews
9.5
Effective treatment
I am absolutely delighted! This is not my first order; I have previously bought numerous domestic proteins, all of which were a complete waste of money. However, this American protein is by far the best I have tried. I noticed an instant effect from it. I am exceptionally pleased and have ordered more creatine from this company.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.5
9.5
Impact of protein therapy on SAPHO
SAPHO syndrome with bone destruction in the lumbar vertebral endplates: a case report.
Evaluates protein treatment effectiveness
We explored the case of a young woman suffering from SAPHO syndrome, a rare inflammatory condition linked to autoimmune disorders. She presented with painful symptoms such as low back pain and joint discomfort, along with skin issues like acne. Despite utilizing high doses of non-steroidal anti-inflammatory drugs, her condition showed no improvement.
The patient was then treated with adalimumab, a type of protein therapy, which was administered bi-weekly. We observed remarkable changes; shortly after starting the treatment, both the disease activity and functional assessments improved significantly. This led to a steady reduction in symptoms, and after three years, she enjoyed a complete relief from pain, showing no signs of worsening bone damage.
This case highlights the potential effectiveness of protein treatment for managing autoimmune disorders like SAPHO syndrome. It demonstrates that when other treatments fail, adalimumab may offer hope and significant relief to patients struggling with such complexities.
The patient was then treated with adalimumab, a type of protein therapy, which was administered bi-weekly. We observed remarkable changes; shortly after starting the treatment, both the disease activity and functional assessments improved significantly. This led to a steady reduction in symptoms, and after three years, she enjoyed a complete relief from pain, showing no signs of worsening bone damage.
This case highlights the potential effectiveness of protein treatment for managing autoimmune disorders like SAPHO syndrome. It demonstrates that when other treatments fail, adalimumab may offer hope and significant relief to patients struggling with such complexities.
Read More
9.5
Effective treatment for autoimmune encephalopathy
Acute onset of anti-IgLON5 disease with meningeal enhancement: a case report.
Moderate relevance regarding treatment effectiveness
We explored the intriguing case of a 78-year-old man diagnosed with anti-IgLON5 disease. This autoimmune condition is known for its unique symptoms and often unpredictable behavior. In this instance, the patient experienced sudden onset of encephalopathy, which included fever and altered consciousness—unusual first signs for this condition.
Imaging studies revealed surprising findings, including thickening and enhancement of the dura mater, as well as lesions in various brain regions. With the detection of IgLON5 antibodies in both his serum and cerebrospinal fluid (CSF), we were able to confirm the diagnosis of anti-IgLON5 disease. Treatment with intravenous methylprednisolone and immunoglobulin proved successful; the patient showed remarkable improvement shortly thereafter, with follow-up imaging indicating resolution of the abnormal findings.
While this case underscores the potential effectiveness of certain protein treatments in mitigating symptoms of autoimmune disorders, it also emphasizes the need for comprehensive diagnostics. The swift response to treatment not only alleviated symptoms but also significantly improved the patient's quality of life. Timeliness in diagnosis and the use of immune therapies appear to be key factors in managing such complex diseases.
Imaging studies revealed surprising findings, including thickening and enhancement of the dura mater, as well as lesions in various brain regions. With the detection of IgLON5 antibodies in both his serum and cerebrospinal fluid (CSF), we were able to confirm the diagnosis of anti-IgLON5 disease. Treatment with intravenous methylprednisolone and immunoglobulin proved successful; the patient showed remarkable improvement shortly thereafter, with follow-up imaging indicating resolution of the abnormal findings.
While this case underscores the potential effectiveness of certain protein treatments in mitigating symptoms of autoimmune disorders, it also emphasizes the need for comprehensive diagnostics. The swift response to treatment not only alleviated symptoms but also significantly improved the patient's quality of life. Timeliness in diagnosis and the use of immune therapies appear to be key factors in managing such complex diseases.
Read More
9.5
Calcium's role in RA treatment
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis.
Focus on calcium's therapeutic potential
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Read More
9
Targeted HS delivery alleviates RA
NaHS@Cy5@MS@SP nanoparticles improve rheumatoid arthritis by inactivating the Hedgehog signaling pathway through sustained and targeted release of HS into the synovium.
High relevance to RA treatment
We explored a new strategy to treat rheumatoid arthritis (RA) by using nanoparticles to deliver hydrogen sulfide (HS) directly to affected joints. Our research focused on how effectively these nanoparticles, called NaHS@Cy5@MS@SP, could target specific cells involved in inflammation and tissue damage in RA. By slowly releasing HS in the synovium, we aimed to combat the negative effects of inflammation caused by fibroblast-like synoviocytes (FLSs).
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
Read More
9
Hydrogel enhances uveitis treatment
Peptide-based hydrogel co-assembled with antibody-drug for enhanced retinal cell uptake and attenuated experimental autoimmune uveitis.
Directly addresses autoimmune treatment
We investigated a new approach to tackle chronic autoimmune eye diseases like uveitis. Our attention focused on a unique drug delivery system that combines a peptide-based hydrogel with secukinumab (SEK), an antibody specifically designed to neutralize IL-17A. This combination targets retinal pigmented epithelium (RPE) cells, helping to enhance the treatment's effectiveness.
Through our analysis, we found that this SEK-loaded hydrogel significantly improved the uptake of the antibody by RPE cells, achieving an impressive 3.7 times increase compared to using SEK alone. Over a 20-day treatment period, we observed that this method also led to higher drug concentrations in the retinal tissues, indicating a more effective delivery mechanism.
In a model of uveitis, just a single intravitreal injection of the SEK-loaded hydrogel was able to effectively suppress inflammation. Moreover, it positively influenced various factors like reducing the activity of specific immune cells, preserving the integrity of the blood-retina barrier, lessening retinal cell death, and supporting the recovery of retinal function. Overall, our study showcases the promising potential of this innovative delivery system for treating complex autoimmune disorders in the eye.
Through our analysis, we found that this SEK-loaded hydrogel significantly improved the uptake of the antibody by RPE cells, achieving an impressive 3.7 times increase compared to using SEK alone. Over a 20-day treatment period, we observed that this method also led to higher drug concentrations in the retinal tissues, indicating a more effective delivery mechanism.
In a model of uveitis, just a single intravitreal injection of the SEK-loaded hydrogel was able to effectively suppress inflammation. Moreover, it positively influenced various factors like reducing the activity of specific immune cells, preserving the integrity of the blood-retina barrier, lessening retinal cell death, and supporting the recovery of retinal function. Overall, our study showcases the promising potential of this innovative delivery system for treating complex autoimmune disorders in the eye.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Effective treatment
I am absolutely delighted! This is not my first order; I have previously bought numerous domestic proteins, all of which were a complete waste of money. However, this American protein is by far the best I have tried. I noticed an instant effect from it. I am exceptionally pleased and have ordered more creatine from this company.
Read More
